How a biotech revolution catapulted this East Bay company to a $100M IPO

10X Genomics
The founders of 10x Genomics (from left) Ben Hindson, Kevin Ness and Serge Saxonov work from their labs in Pleasanton in 2015.
Conner Jay
Ron Leuty
By Ron Leuty – Senior Reporter, San Francisco Business Times

This company has helped fuel the revolution in single-cell sequencing, which has accelerated discoveries in cancer, immunology and neuroscience.

A fast-growing East Bay biotech tools maker — whose cell-probing technologies have helped revolutionize medical research as well as burden it with patent infringement suits — filed Monday for a $100 million initial public offering.

10X Genomics Inc. of Pleasanton wants to use IPO proceeds for working capital, operating expenses and, possibly, acquisitions as it expands its offerings of so-called single-cell sequencing technologies. The underlying technology allows researchers to peer closely at genes and single cells, part of a revolution that has led to discoveries and new understandings across a range of diseases.

It is a rare life sciences IPO: As a maker of equipment that helps academic and commercial research operations get a closer look at cells, it actually has revenue.

10X, whose stock would trade on the Nasdaq exchange as "TXG," reported a $112.5 million loss last year on revenue of $146.3 million. Its largest investors include San Francisco's Foresite Capital Management at 18.1 percent, Venrock of Palo Alto (16.3 percent), Paladin Capital Group (11.5 percent) and Fidelity (11.3 percent).

The 7-year-old, 500-employee company, which has grown from 110 employees since the end of 2015, had an accumulated deficit of $245.6 million at the end of June. It had cash and equivalents of $56 million as of June 30.

Last October, the San Francisco Business Times recognized 10X as the fastest-growing Bay Area company, based on 2015-17 revenue growth.

Yet the company's growth since it was founded by CEO Serge Saxonov, President Benjamin Hindson and Kevin Ness, has taken a hit with a patent-infringement suits brought by Bio-Rad Laboratories Inc. (NYSE: BIO) of Hercules and others. One of those suits resulted in a final judgment this month of $35 million and a 15 percent royalty on prior sales and an injunction against using that microfluidic chip technology that constitutes "substantially all" of 10X's product sales, the company said in a filing with the Securities and Exchange Commission.

Bio-Rad also has asked the U.S. International Trade Commission to prevent 10X from importing the microfluidic chips, and a judge recommended an exclusion order. A cease and desist order could take effect in November, the company said.

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